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EZH2: Enzyme That Promotes Cancer May Also Prevent It

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May Help Researchers Stop the Process of Tumor Development

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Published Jan 12, 2006 by Terri Rimmer
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Did you know?
Cancer will affect 1 in 3 individuals.
Takeaways
· EZH2 is a biomarker enzyme.
· Leandra Smith was diagnosed with cancer in 1996.
· Terry Healey was diagnosed with a disfiguring cancer.
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An enzyme that promotes cancer may prevent it according to new research at M.D. Anderson Cancer Center.
A protein that identifies aggressiveness appears in two forms, according to CancerWise, a publication of the Center.

Scientists have discovered that a protein that suppresses cancer growth might also encourage it and researchers may have found a way to stop that process of tumor development according to new study results.

In a recent issue of the journal Science, M.D. Anderson scientists reported that when a protein called EZH2 is in its "native" state it suppresses cancer cell growth and works to inhibit cancer development.

In the study the researchers developed a "mutant" protein that stops EXH2 from being phosphorylated, says the study's lead author, Mien-Chie Hung, Ph.D., chair of Anderson's Department of Molecular and Cellular Oncology.

EZH2 is a biomarker enzyme, which means the protein is used to measure aggressiveness of certain types of cancer.

"This has become a big riddle to cancer researchers who want to be able to use EZH2 as a marker upon which to base aggressive treatment," Hung says.

Leandra Smith, who was diagnosed with cancer in 1996, found the ocean to be a respite. She died in 1998 after a long battle.

Terry Healey, who suffered from a disfiguring cancer, published a book about his experience.

"I was a junior at the University of California at Berkeley when I was diagnosed," he said. "Five years later and after numerous attempts to reconstruct my face I was still dealing with the insecurity."

Linda Carpenter was diagnosed with cancer in 1992 and went through chemotherapy and surgery.

"I guess there is never a good time to have cancer but at the time I thought, ‘I don't have time to have cancer," she said. "I was divorced, mother of three boys and was caring for my terminally ill fiancĂ©e who had cancer."

Aurore, 14, thought she had an infection but it turned out to be cancer.
"If you have a lump or your family has a history of cancer, go to the doctor and get it checked," she said.

Lifetime Television has an 11-year-old Stop Cancer For Life Campaign.

Elaine Newman, who was diagnosed with lung cancer at the age of 42, started her own little fundraiser to raise awareness for the disease.

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